Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice
Compared to survivors, the lethal phenotype induced a stronger deregulation of amine metabolism and cytokine expression in selected brain regions, but the BBB permeability remained similar regardless of the predicted outcome.
Authors
- Hermann Mascher
- Daniel Mascher
- Barbara Bauder
- Nora Dinhopl (ORCID: https://orcid.org/0000-0002-0736-0549)
- Alexander Tichy (ORCID: https://orcid.org/0000-0001-8668-3858)
- Sandra Högler (ORCID: https://orcid.org/0000-0002-6899-5273)
- Fatemeh Azizian-Farsani
- Andrea Klang (ORCID: https://orcid.org/0000-0001-5352-5757)
- Herbert Weißenböck (ORCID: https://orcid.org/0000-0001-8197-6379)
- Marcin F. Osuchowski (ORCID: https://orcid.org/0000-0002-1321-9883)
- Katrin M. Weixelbaumer
- Peter Schmidt
Institutions
- University of Veterinary Medicine Vienna (AT)
- Ionicon Analytik (Austria) (AT)
- Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA (AT)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s40635-024-00688-7
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.42