MSC–microvesicles protect cartilage from degradation in early rheumatoid arthritis via immunoregulation
MSCs-MVs can inhibit the decomposition of the inflammation-induced cartilage matrix by regulating immune cell inflammatory factors to attenuate cartilage destruction. MSC-MVs are promising effective treatments for the early stages of RA.
Authors
- Shixiong Wei (ORCID: https://orcid.org/0000-0002-1370-7967)
- Xinping Tian (ORCID: https://orcid.org/0000-0002-1511-7952)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0002-3883-2318)
- Rui-Juan Cheng
- Qiuhong Wu (ORCID: https://orcid.org/0000-0003-1253-1899)
- Yi Liu (ORCID: https://orcid.org/0000-0002-6592-9262)
- Chenyang Lu (ORCID: https://orcid.org/0000-0001-9128-6769)
- Qiuping Zhang (ORCID: https://orcid.org/0000-0002-2633-5824)
- Xueting Zhao (ORCID: https://orcid.org/0000-0002-6513-4902)
- Sujia Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Peking Union Medical College Hospital (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12951-024-02922-6
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Sichuan University
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University