Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
ALE, RRMS, and pCNS-tumors show distinct but partially overlapping changes mainly in HLA-DR<sup>+</sup> Tc, memory Tc, exhausted Tc, and Bc subsets providing insights into disease pathogenesis. Moreover, mFC shows diagnostic potential facilitating early diagnosis and treatment.
Authors
- Kristin S. Golombeck
- Guido Reifenberger (ORCID: https://orcid.org/0000-0002-1419-9837)
- Melanie Korsen (ORCID: https://orcid.org/0000-0003-2882-002X)
- Marion Rapp (ORCID: https://orcid.org/0000-0003-2343-244X)
- Norbert Goebels
- Christina B. Schroeter (ORCID: https://orcid.org/0000-0002-1391-7817)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Sumanta Barman (ORCID: https://orcid.org/0000-0002-4485-402X)
- Heinz Wiendl (ORCID: https://orcid.org/0000-0003-4310-3432)
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Lars Masanneck (ORCID: https://orcid.org/0000-0003-2496-1415)
- Tobias Ruck (ORCID: https://orcid.org/0000-0001-6332-8650)
- Oliver Grauer
- Michael Hanke (ORCID: https://orcid.org/0000-0003-4950-6646)
- Stefanie Lichtenberg (ORCID: https://orcid.org/0000-0003-4703-2571)
- Andreas Schulte‐Mecklenbeck (ORCID: https://orcid.org/0000-0003-3855-4706)
- Werner Paulus (ORCID: https://orcid.org/0000-0001-6472-8162)
- Andre Dik (ORCID: https://orcid.org/0000-0003-4695-4136)
- Alice Willison (ORCID: https://orcid.org/0000-0002-0719-8334)
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Christine Strippel (ORCID: https://orcid.org/0000-0002-7080-6769)
- Marc Pawlitzki (ORCID: https://orcid.org/0000-0003-3080-2277)
- Michael Sabel (ORCID: https://orcid.org/0009-0000-1485-7820)
- Katharina Johanna Weber (ORCID: https://orcid.org/0000-0001-9395-8944)
- Marco Gallus (ORCID: https://orcid.org/0009-0007-4954-8420)
- Ruth Kerkhoff
- Duygu Pul
- Stjepana Kovac (ORCID: https://orcid.org/0000-0002-5571-9237)
- Catharina C. Gross
- M Jonas
- Ramona Hagler
Institutions
- Goethe University Frankfurt (DE)
- Forschungszentrum Jülich (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Münster (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Münster (DE)
- University Hospital Frankfurt (DE)
- Frankfurt Cancer Institute (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12974-024-03269-3
- Citations
- 6
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Bundesministerium für Bildung und Forschung
- Heinrich-Heine-Universität Düsseldorf
- Deutsche Krebshilfe