Analysis of Glycyrrhiza Glabra Phytocompounds using Network Pharmacology for Anti-Alzheimer Therapy

Alzheimer’s disease (AD) is a highly complex and neurodegenerative disease that has clinical symptoms like memory loss along with degrading cognitive functioning. The rise in the prevalence of this diseases in recent years attributed to modern lifestyle by various studies has created a crucial requirement to comprehend AD pathophysiology and create effective treatment plans. The intricacy and difficulty of both the disease and its underlying causes are demonstrated by the fact that over 200 viable medication candidates have failed clinical trials and that the advancement of AD is unaffected by the pharmaceutical techniques produced to date. The central pathophysiology of the disease has shown that AD is characterized by amyloid plaques of β-amyloid peptide. To overcome the complexities associated with AD, scientific investigations have shifted their focus towards the plant compounds resent in the ecosystem. Many plants and their compounds have shown efficacy for treating AD. In this paper we have studied all the phytocompounds of plant Glycyrrhiza glabra, known to contain potential anti- Alzheimers phyto compounds for therapeutic purposes. By utilizing the techniques of network pharmacology combined with molecular docking analysis, this paper provides a potential pathway to find new drugs and modify existing drugs based upon observations made by studying multiple compounds-target interactions.