A single dose recombinant AAV based CHIKV vaccine elicits robust and durable protective antibody responses in mice
The rAAV1-CHIKV-SP showed remarkable safety and immunogenicity in C57BL/6 mice. A single dose intramuscular injection of rAAV1-CHIKV-SP elicited high level and long-lasting antibody responses, and conferred complete protection against a heterologous CHIKV strain challenge. These results suggest rAAV1-CHIKV-SP represents a promising vaccine candidate against different CHIKV clades with a simplified immunization strategy.
Authors
- Hongqing Zhang (ORCID: https://orcid.org/0000-0002-9125-7914)
- Chengcheng Leng (ORCID: https://orcid.org/0009-0000-2946-4149)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-8895-3679)
- Yanan Zhang (ORCID: https://orcid.org/0000-0002-6424-7913)
- Xiaodan Li (ORCID: https://orcid.org/0000-0002-4953-6709)
- Cheng-Lin Deng (ORCID: https://orcid.org/0009-0000-2819-6533)
- Jiajia Li (ORCID: https://orcid.org/0000-0001-6743-2797)
- Xixi Ye
- Qin-Xuan Zhu
- Xin Wang (ORCID: https://orcid.org/0000-0002-6229-1945)
Institutions
- Hunan Normal University (CN)
- Chinese Academy of Sciences (CN)
- Changsha Normal University (CN)
- Wuhan Institute of Virology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1371/journal.pntd.0012604
- Citations
- 5
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 2.71