A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors
The present model represents a valuable framework for studying the intricate interactions within the plasma KKS and provides a better understanding of the mechanism of action of various KKS-targeted therapies.
Authors
- Matthias Pelzing (ORCID: https://orcid.org/0009-0001-9651-8757)
- Ineke Muir (ORCID: https://orcid.org/0000-0002-8209-1385)
- Steven Dower (ORCID: https://orcid.org/0000-0002-4675-4225)
- Alireza Rezvani-Sharif (ORCID: https://orcid.org/0000-0001-6595-2596)
- Con Panousis (ORCID: https://orcid.org/0000-0002-4478-3129)
- Hadi Lioe
- Dalton J. E. Harvie (ORCID: https://orcid.org/0000-0002-8501-1344)
Institutions
- The University of Melbourne (AU)
- CSL (Australia) (AU)
Publication Details
- Journal
- PLoS Computational Biology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1371/journal.pcbi.1012552
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.31