Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning
The brain-predicted DD gap is sensitive to MS-related lesions and brain atrophy, adds to the brain-age paradigm in explaining physical disability both cross-sectionally and longitudinally, and may be used as an MS-specific biomarker of disease severity and progression.
Authors
- Daniela Pinter (ORCID: https://orcid.org/0000-0003-3138-5225)
- Einar August Høgestøl (ORCID: https://orcid.org/0000-0001-8446-2111)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- James H. Cole (ORCID: https://orcid.org/0000-0003-1908-5588)
- Manuela Vaněčková (ORCID: https://orcid.org/0000-0002-8784-7997)
- Ahmed Toosy (ORCID: https://orcid.org/0000-0002-4441-3750)
- Carsten Lukas (ORCID: https://orcid.org/0000-0002-8562-9697)
- Sara Llufriú (ORCID: https://orcid.org/0000-0003-4273-9121)
- Gabriel González‐Escamilla (ORCID: https://orcid.org/0000-0002-7209-1736)
- Charmaine Yam (ORCID: https://orcid.org/0000-0002-4146-2047)
- Michael A. Foster (ORCID: https://orcid.org/0000-0001-7201-7475)
- Jaume Sastre‐Garriga (ORCID: https://orcid.org/0000-0002-1589-2254)
- Eloy Martínez‐Heras (ORCID: https://orcid.org/0000-0001-9937-3162)
- Sergiu Groppa (ORCID: https://orcid.org/0000-0002-2551-5655)
- Alvino Bisecco (ORCID: https://orcid.org/0000-0002-7202-4445)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-4930-7639)
- Christian Enzinger (ORCID: https://orcid.org/0000-0001-9764-7617)
- Claudio Gasperini (ORCID: https://orcid.org/0000-0002-3959-4067)
- Tomáš Uher (ORCID: https://orcid.org/0000-0003-3160-9022)
- Omar Abdel‐Mannan (ORCID: https://orcid.org/0000-0002-0796-9645)
- Giuseppe Pontillo (ORCID: https://orcid.org/0000-0001-5425-1890)
- Yael Hacohen (ORCID: https://orcid.org/0000-0001-8490-9657)
- Paola Valsasina (ORCID: https://orcid.org/0000-0001-5390-2655)
- Rosa Cortese (ORCID: https://orcid.org/0000-0002-9803-7914)
- Marco Castellaro (ORCID: https://orcid.org/0000-0002-1203-2670)
- Jed Wingrove (ORCID: https://orcid.org/0000-0002-0454-1299)
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Gro Owren Nygaard (ORCID: https://orcid.org/0000-0002-4913-8567)
- Sarmad Al‐Araji
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Serena Ruggieri (ORCID: https://orcid.org/0000-0001-5287-3290)
- Anna He (ORCID: https://orcid.org/0000-0002-6924-8798)
- Maria Petracca (ORCID: https://orcid.org/0000-0001-9429-2769)
- Sara Collorone (ORCID: https://orcid.org/0000-0003-1506-8983)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Hanne F. Harbo (ORCID: https://orcid.org/0000-0002-6047-0122)
- Àlex Rovira (ORCID: https://orcid.org/0000-0002-2132-6750)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Suraya Mohamud
- Olga Ciccarelli (ORCID: https://orcid.org/0000-0001-7485-1367)
- Massimiliano Calabrese (ORCID: https://orcid.org/0000-0002-3362-7403)
- Wallace Brownlee (ORCID: https://orcid.org/0000-0003-0481-8902)
- Baris Kanber (ORCID: https://orcid.org/0000-0003-2443-8800)
- Hugo Vrenken (ORCID: https://orcid.org/0000-0001-9106-1172)
- Ronja Christensen (ORCID: https://orcid.org/0000-0002-5101-0896)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Sirio Cocozza (ORCID: https://orcid.org/0000-0002-0300-5160)
- Alessia Bianchi (ORCID: https://orcid.org/0000-0001-5541-5818)
- Silvia Messina (ORCID: https://orcid.org/0000-0002-1134-5771)
- Jordan Colman (ORCID: https://orcid.org/0000-0002-6028-504X)
- Tarek Yousry (ORCID: https://orcid.org/0000-0003-3295-0628)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Elisa Colato (ORCID: https://orcid.org/0000-0002-4101-7058)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Marcello Moccia (ORCID: https://orcid.org/0000-0003-2613-3090)
- Barbara Bellenberg (ORCID: https://orcid.org/0000-0001-7484-6787)
- Antonio Gallo (ORCID: https://orcid.org/0000-0002-2203-6237)
- Arturo Brunetti (ORCID: https://orcid.org/0000-0001-7057-3494)
- Jacqueline A. Palace (ORCID: https://orcid.org/0000-0003-4779-6133)
- Ludwig Kappos
- Riccardo Nistri (ORCID: https://orcid.org/0000-0002-5479-8201)
Institutions
- Anna Needs Neuroblastoma Answers (US)
- University College London (GB)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1212/wnl.0000000000209976
- Citations
- 13
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.52
Funders
- National Science Foundation
- Bristol-Myers Squibb
- Eli Lilly and Company
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Fondazione Italiana Sclerosi Multipla
- European Committee for Treatment and Research in Multiple Sclerosis
- International Progressive MS Alliance
- Argenx
- National Institute for Health and Care Research
- European Commission
- Rosetrees Trust
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung
- Ministero della Salute
- Ministerstvo Zdravotnictví Ceské Republiky
- Novo Nordisk
- Norges Forskningsråd
- Fondation Charcot
- University College London Hospitals NHS Foundation Trust
- Ipsen
- Všeobecná Fakultní Nemocnice v Praze
- Chugai Pharmaceutical
- Medical Research Council