Cellular oxygen consumption in patients with diabetic ketoacidosis
Mitochondrial metabolic profiles of patients with DKA demonstrated lower cellular oxygen consumption when compared to healthy controls. Oxygen consumption increased significantly in cells of patients with DKA treated with thiamine or CoQ10. These results suggest that thiamine and CoQ10 could potentially have therapeutic benefits in DKA via their metabolic effects on mitochondrial cellular respiration.
Authors
- John H. Lee (ORCID: https://orcid.org/0000-0003-3699-5161)
- Katherine M. Berg (ORCID: https://orcid.org/0000-0003-1897-1086)
- Jacob Vine (ORCID: https://orcid.org/0000-0001-5254-2694)
- Lakshman Balaji (ORCID: https://orcid.org/0000-0001-7189-4775)
- Natia Peradze
- Michael W. Donnino (ORCID: https://orcid.org/0000-0002-8541-8099)
- Noa Berlin (ORCID: https://orcid.org/0000-0002-9276-5208)
- Anne V. Grossestreuer (ORCID: https://orcid.org/0000-0001-7316-5576)
- Ari Moskowitz (ORCID: https://orcid.org/0000-0002-0194-990X)
- Xiaowen Liu (ORCID: https://orcid.org/0000-0001-6030-8179)
- Max S. Kravitz (ORCID: https://orcid.org/0009-0009-1834-2221)
- Shannon B. Leland (ORCID: https://orcid.org/0000-0002-2239-7120)
- Andrea Morton
- Nivedha Antony
Institutions
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Montefiore Medical Center (US)
- The Bronx Defenders (US)
- Invicro (United States) (US)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s40635-024-00673-0
- Citations
- 2
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases