An objective quantitative diagnosis of depression using a local-to-global multimodal fusion graph neural network
This study developed an artificial intelligence (AI) system using a local-global multimodal fusion graph neural network (LGMF-GNN) to address the challenge of diagnosing major depressive disorder (MDD), a complex disease influenced by social, psychological, and biological factors. Utilizing functional MRI, structural MRI, and electronic health records, the system offers an objective diagnostic method by integrating individual brain regions and population data. Tested across cohorts from China, Japan, and Russia with 1,182 healthy controls and 1,260 MDD patients from 24 institutions, it achieved a classification accuracy of 78.75%, an area under the receiver operating characteristic curve (AUROC) of 80.64%, and correctly identified MDD subtypes. The system further discovered distinct brain connectivity patterns in MDD, including reduced functional connectivity between the left gyrus rectus and right cerebellar lobule VIIB, and increased connectivity between the left Rolandic operculum and right hippocampus. Anatomically, MDD is associated with thickness changes of the gray and white matter interface, indicating potential neuropathological conditions or brain injuries.
Authors
- Ruoxi Wang (ORCID: https://orcid.org/0009-0002-4824-1316)
- Cheng Jin (ORCID: https://orcid.org/0000-0002-0430-703X)
- Xuequan Zhu (ORCID: https://orcid.org/0000-0001-5551-2810)
- Zhiyu Yang (ORCID: https://orcid.org/0000-0003-3405-3015)
- Shuyu Liu (ORCID: https://orcid.org/0009-0000-3819-7820)
- Shaoting Zhang (ORCID: https://orcid.org/0000-0002-8719-448X)
- Nevin L. Zhang (ORCID: https://orcid.org/0000-0002-4662-3217)
- Gang Wang (ORCID: https://orcid.org/0000-0002-7266-2412)
- Yanfeng Wang (ORCID: https://orcid.org/0000-0001-7873-6577)
- Yizhe Yuan (ORCID: https://orcid.org/0009-0007-8602-6322)
- Jingjing Zhou (ORCID: https://orcid.org/0000-0001-5859-9827)
- Ziji Wang
- Xinzhu Zhou
- Xiongying Chen
- Xin Fang (ORCID: https://orcid.org/0000-0002-4049-547X)
- Ya Zhang (ORCID: https://orcid.org/0000-0002-2464-392X)
Institutions
- Swarthmore College (US)
- Shanghai Jiao Tong University (CN)
- Beijing Academy of Artificial Intelligence (CN)
- Beijing Anding Hospital (CN)
- Institute of Psychology, Chinese Academy of Sciences (CN)
- Wuhu Hit Robot Technology Research Institute (CN)
- University of Chinese Academy of Sciences (CN)
- Shanghai Artificial Intelligence Laboratory (CN)
- Stanford University (US)
Publication Details
- Journal
- Patterns
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1016/j.patter.2024.101081
- Citations
- 10
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- National Key Research and Development Program of China