Intracranial pleomorphic liposarcoma misclassified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier: illustrative case
In this report, the authors describe the case of a patient with an intracranial pleomorphic LPS that was initially classified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier. Although DNA methylation classifiers are useful as diagnostic aids in cases in which definitive pathology is difficult to determine, there is a risk of misdiagnosis in some types of tumors. https://thejns.org/doi/10.3171/CASE24465.
Authors
- Shigeki Takada (ORCID: https://orcid.org/0000-0003-2977-888X)
- Hironori Haga (ORCID: https://orcid.org/0000-0003-4322-9561)
- Masahiro Tanji (ORCID: https://orcid.org/0009-0002-2459-1856)
- Masato Hojo (ORCID: https://orcid.org/0000-0001-7517-2622)
- Yasuhide Takeuchi (ORCID: https://orcid.org/0000-0002-1262-2355)
- Yoshiki Arakawa (ORCID: https://orcid.org/0000-0003-4626-4645)
- Sachiko Minamiguchi (ORCID: https://orcid.org/0000-0002-5800-6769)
- Yohei Mineharu (ORCID: https://orcid.org/0000-0002-6346-3999)
- Noritaka Sano (ORCID: https://orcid.org/0000-0002-8999-1976)
- Kohichi Go
- Yasuhide Makino
Institutions
- Kyoto University (JP)
- Shiga Medical Center (JP)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3171/case24465
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development