A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice
The high effectiveness of Bio-nFeR in the neuT model of mammary carcinogenesis, coupled with its low toxicity, indicates this formulation as a potential candidate for the treatment of metastatic BC and for the adjuvant therapy of BC patients at high risk of developing metastasis.
Authors
- Cristina Matteo (ORCID: https://orcid.org/0000-0001-8910-1104)
- Elena Petricci (ORCID: https://orcid.org/0000-0002-9685-6342)
- Ann Zeuner (ORCID: https://orcid.org/0000-0002-8295-3715)
- Maria Laura De Angelis (ORCID: https://orcid.org/0000-0003-4220-8822)
- Alessandra Boe (ORCID: https://orcid.org/0000-0002-8888-7501)
- Federica Francescangeli (ORCID: https://orcid.org/0000-0002-1086-5265)
- Rachele Rossi (ORCID: https://orcid.org/0000-0002-7570-2934)
- Massimo Zucchetti (ORCID: https://orcid.org/0000-0002-5427-052X)
- Anna Maria Pacca
- Adriana Eramo (ORCID: https://orcid.org/0000-0002-0814-6683)
- Eleonora Aricò (ORCID: https://orcid.org/0000-0003-4728-9246)
- Isabella Orienti (ORCID: https://orcid.org/0000-0003-1972-2807)
- Marta Baiocchi (ORCID: https://orcid.org/0000-0003-0976-0690)
- Emanuela Pilozzi (ORCID: https://orcid.org/0000-0002-7110-9172)
- Paola Verachi
- Tiberio Corati
- Daniele Macchia
Institutions
- University of Siena (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Istituto Superiore di Sanità (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s13046-024-03213-6
- Citations
- 6
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Fondazione Italiana per la Ricerca sul Cancro