GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease
We identify GLIS3 as a novel positive regulator of the transition from aerobic glycolysis to OXPHOS in normal early postnatal kidney development by directly regulating the transcription of mitochondrial metabolic genes. Loss of GLIS3 induces several features of renal cell metabolic reprogramming. Our study identifies GLIS3 as a new participant in an interconnected transcription regulatory network, that includes HNF1B and NRF1, critical in the regulation of mitochondrial-related gene expression and energy metabolism in normal postnatal kidneys and PKD pathogenesis in Glis3-deficient mice.
Authors
- Anton M. Jetten (ORCID: https://orcid.org/0000-0003-0954-4445)
- Sara A. Grimm (ORCID: https://orcid.org/0000-0003-3050-1909)
- Justin B. Collier (ORCID: https://orcid.org/0000-0001-5302-2826)
- Yun-Gil Roh
- Chitrangda Srivastava (ORCID: https://orcid.org/0000-0001-5513-9198)
- Hong Soon Kang (ORCID: https://orcid.org/0000-0003-2230-8797)
- Alan K. Jarmusch (ORCID: https://orcid.org/0000-0002-2228-6308)
Institutions
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.molmet.2024.102052
- Citations
- 8
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences