TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway
Our data collectively revealed a pathological feedback loop involving TRPM2, Ca<sup>2+</sup>, mtDNA, cGAS, STING, and NF-κB in OA chondrocytes. This suggests that disrupting this loop could be a viable therapeutic approach for OA.
Authors
- Yanjun Hou (ORCID: https://orcid.org/0000-0003-3077-670X)
- Fengjing Guo (ORCID: https://orcid.org/0000-0002-5968-4836)
- Zhaoxuan Ruan (ORCID: https://orcid.org/0009-0006-4652-1735)
- Liangcai Hou (ORCID: https://orcid.org/0000-0003-1368-9823)
- Kaixiang Yang (ORCID: https://orcid.org/0000-0001-9289-8900)
- Zehang Zheng
- Haigang Liu (ORCID: https://orcid.org/0000-0001-8848-2988)
- Fan Lü (ORCID: https://orcid.org/0000-0003-0846-147X)
- Kai Sun (ORCID: https://orcid.org/0000-0002-1929-0453)
- Jingting Xu (ORCID: https://orcid.org/0000-0002-4644-0170)
- Junchen He
- Zhou Guo (ORCID: https://orcid.org/0000-0001-9043-9196)
- Xiong Zhang
Institutions
- Wuhan Puai Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1016/j.jare.2024.11.007
- Citations
- 18
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province