METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway
The increased expression of KIF15 was found to be associated with the progression of NPC and play a role in the development of radioresistance in NPC. Inhibiting KIF15 was shown to impede tumor growth and improve the sensitivity of NPC to radiotherapy by triggering autophagy via the STAT3/ATG7 pathway.
Authors
- Guoliang Pi (ORCID: https://orcid.org/0000-0002-2740-2857)
- Lifang Tian (ORCID: https://orcid.org/0000-0001-9312-9206)
- Xiaofeng Wu (ORCID: https://orcid.org/0000-0002-8961-2163)
- Shuibin Wang (ORCID: https://orcid.org/0000-0002-0307-7658)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-7141-6730)
- Siwei Li
- Jiahua Zou
Institutions
- Wuhan University of Technology (CN)
- Huanggang Central Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.tranon.2024.102161
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10