High-Sensitivity and Conventional Cardiac Troponin-I Assays in AL Amyloidosis
Overall agreement was demonstrated; however, a negative bias for HS-cTnI assay was noted at low concentrations. The application of the conventional cTnI threshold of >100 ng/L to HS-cTnI-based Boston University cardiac staging showed a trend toward downgraded staging assignments. The prognostic utility of HS-cTnI assay in biomarker staging warrants further investigation in patients with AL amyloidosis.
Authors
- Tatiana Prokaeva (ORCID: https://orcid.org/0000-0002-0790-602X)
- Vaishali Sanchorawala (ORCID: https://orcid.org/0000-0002-6307-2445)
- Lisa Mendelson (ORCID: https://orcid.org/0000-0003-2821-6009)
- Yachana Kataria (ORCID: https://orcid.org/0000-0002-6249-7134)
- Tracy Joshi (ORCID: https://orcid.org/0000-0003-4048-6271)
- Maura C Dodge
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Amyloidosis Foundation (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1093/jalm/jfae111
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00