From burst to controlled release: using hydrogel crosslinking chemistry to tune release of micro-crystalline active pharmaceutical ingredients
In this study, a nanoemulsion of a BCS class II drug, fenofibrate, was cross-linked via a Michael-type addition reaction to yield micro-crystalline Fen-embedded micro-hydrogels with tunable degradation.
Authors
- Purnima Naresh Manghnani (ORCID: https://orcid.org/0000-0002-1821-4416)
- Saif A. Khan (ORCID: https://orcid.org/0000-0002-8990-8802)
- Patrick S. Doyle (ORCID: https://orcid.org/0000-0003-2147-9172)
- Arif Z. Nelson (ORCID: https://orcid.org/0000-0002-4539-0968)
- Kelvin Wong (ORCID: https://orcid.org/0009-0003-4036-2727)
- Yi Wei Lee
Institutions
- Harvard University (US)
- National University of Singapore (SG)
- Harvard Affiliated Emergency Medicine Residency (US)
- Université Bourgogne Franche-Comté (FR)
- Singapore-MIT Alliance for Research and Technology (SG)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1039/d4pm00186a
- Citations
- 8
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 1.66