Comparative genomics of Plasmodium yoelii nigeriensis N67 and N67C: genome-wide polymorphisms, differential gene expression, and drug resistance
The identification of polymorphic sites between the N67 and N67C genomes, along with the detection of the DEGs, may provide crucial insights into the variations in parasite drug responses and disease severity between these two isogenic parasites. The functional characterization of these genetic differences and candidate genes will deepen our understanding of disease mechanisms and pave the way for developing more effective control measures against malaria.
Authors
- Fangzheng Xu
- Awet Alem Teklemichael
- Cihan Oguz (ORCID: https://orcid.org/0000-0002-2860-3546)
- Osamu Kaneko (ORCID: https://orcid.org/0000-0003-0675-8296)
- Justin Lack (ORCID: https://orcid.org/0000-0003-0584-4010)
- Amuza Byaruhanga Lucky (ORCID: https://orcid.org/0000-0001-6779-1888)
- Shengfa Liu (ORCID: https://orcid.org/0000-0002-2558-6701)
- Xin‐zhuan Su (ORCID: https://orcid.org/0000-0003-3246-3248)
- Rachel V. Stadler (ORCID: https://orcid.org/0000-0002-1049-1638)
- Jian Wu (ORCID: https://orcid.org/0000-0001-5784-6160)
Institutions
- National Institutes of Health (US)
- Xiamen University (CN)
- National Institute of Allergy and Infectious Diseases (US)
- Nagasaki University (JP)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12864-024-10961-4
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research