Exosomes derived from platelet-rich plasma present a novel potential in repairing knee articular cartilage defect combined with cyclic peptide-modified β-TCP scaffold
PRP-exos combined with cyclic peptide-modified β-TCP scaffold effectively promoted cartilage repair and improved chondrocyte function in rabbit knee cartilage defect. Based on the analysis and prediction of PRP-exos miRNAs sequencing, PI3K/AKT signaling pathway may contribute to the therapeutic effect. These findings provide experimental evidence for the application of PRP-exos in the treatment of cartilage defect.
Authors
- Xuchang Liu
- Rudong Chen
- Kechun Liu (ORCID: https://orcid.org/0000-0001-5461-5818)
- Rongjie Feng (ORCID: https://orcid.org/0000-0002-5978-5709)
- Guanzheng Cui
Institutions
- Qilu University of Technology (CN)
- Shandong Provincial Hospital (CN)
- Shandong Academy of Sciences (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s13018-024-05202-z
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34