Efficacy and safety of Shengjiang Xiexin decoction on irinotecan-induced diarrhea in small cell lung cancer patients: a multicenter, randomized, double-blind, placebo-controlled trial
SXD had a prophylactic effect in the diarrhea induced by irinotecan, especially for UGT1A1 high-risk population, and this effect from SXD appeared to be maintained the completion of chemotherapy schedule. The mechanism of action of SXD was related to the regulation of inflammatory factors. Trial registration Chinese Clinical Trial Register: ChiCTR1800018490. Registered on 20 September 2018. https://www.chictr.org.cn/showproj.html?proj=25250 . The preliminary protocol of this clinical study has been published in the journal "Trials" in the form of protocol before this paper (Deng et al. in Trials 21:370, 2020).
Authors
- Shijie Zhu (ORCID: https://orcid.org/0000-0003-1931-7430)
- Huijuan Cui (ORCID: https://orcid.org/0000-0003-2900-0461)
- Guowang Yang (ORCID: https://orcid.org/0000-0002-0799-3864)
- Yu Gao (ORCID: https://orcid.org/0000-0002-4615-3614)
- Zhiguo Zhang (ORCID: https://orcid.org/0000-0003-3982-9900)
- Chao Deng (ORCID: https://orcid.org/0000-0002-2607-5575)
- Qin Li (ORCID: https://orcid.org/0000-0003-3739-0009)
- Liqun Jia (ORCID: https://orcid.org/0000-0002-0370-2126)
- Meng Yang (ORCID: https://orcid.org/0000-0002-5520-0654)
- Yang Ge (ORCID: https://orcid.org/0000-0001-7299-6175)
- Y.-Q. Lou
- Qing Liu (ORCID: https://orcid.org/0009-0008-9320-450X)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- China-Japan Friendship Hospital (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Peking University Third Hospital (CN)
- Beijing Friendship Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s13020-024-01025-6
- Citations
- 3
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- China-Japan Friendship Hospital