Copper-Catalyzed Dearomative [3 + 2] Annulation of Indoles with 2-Iodoacetic Acid
An efficient copper-catalyzed dearomative [3 + 2] annulation of indoles with 2-iodoacetic acid is developed. By employing Cu(OTf)<sub>2</sub>/2,2'-bis(2-oxazoline) as the catalyst and LPO as the oxidant, a series of indoline-fused butyrolactones were synthesized in moderate to good yields. The reaction features mild conditions, a broad substrate scope, and readily available starting materials. Furthermore, synthetic transformations of the products were conducted to demonstrate the practical utility of this reaction.
Authors
- Xuefeng Bai (ORCID: https://orcid.org/0000-0002-8757-7034)
- Yi‐Xia Jia (ORCID: https://orcid.org/0000-0001-7936-0049)
- Ren‐Xiao Liang (ORCID: https://orcid.org/0000-0003-0931-1975)
- Ming‐Hua Mao
- Hu-Jie Cai
- Bao-Yu Du
Institutions
- Tianjin University of Technology (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1021/acs.orglett.4c03213
- Citations
- 7
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province