Actionable Structural Variant Detection via RNA-NGS and DNA-NGS in Patients With Advanced Non–Small Cell Lung Cancer
In this cohort study, the detection of structural variants via concurrent RNA-NGS and DNA-NGS was higher across multiple NCCN-guideline recommended biomarkers compared with DNA-NGS alone, suggesting that RNA-NGS should be routinely implemented in the care of patients with advanced NSCLC.
Authors
- Ezra E.W. Cohen (ORCID: https://orcid.org/0000-0002-9872-6242)
- John Guittar (ORCID: https://orcid.org/0000-0002-8897-8841)
- Rotem Ben‐Shachar (ORCID: https://orcid.org/0000-0002-2717-0259)
- Adam J. Hockenberry (ORCID: https://orcid.org/0000-0001-9476-0104)
- Zachary Rivers (ORCID: https://orcid.org/0000-0002-4957-4908)
- Daniel Morgensztern (ORCID: https://orcid.org/0000-0003-4349-2028)
- Jyoti D. Patel (ORCID: https://orcid.org/0000-0002-7550-2094)
- Halla Nimeiri (ORCID: https://orcid.org/0000-0002-8760-6456)
- Catarina Catela
- Dwight Owen
- Jerod Parsons (ORCID: https://orcid.org/0000-0002-4184-343X)
- Lisa Gai (ORCID: https://orcid.org/0009-0001-0803-5246)
- Josephine Feliciano (ORCID: https://orcid.org/0009-0008-8163-2304)
- Genelle F. Harrison (ORCID: https://orcid.org/0000-0003-3386-8159)
- Justin Guinney (ORCID: https://orcid.org/0000-0003-1477-1888)
- Kyle A. Beauchamp (ORCID: https://orcid.org/0000-0001-6095-8788)
- Kate Sasser (ORCID: https://orcid.org/0009-0009-2804-1684)
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- Tempus Labs (United States) (US)
- The Ohio State University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.42970
- Citations
- 21
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.91