Enhancing Anti-PD-1 Immunotherapy by Targeting MDSCs via Hepatic Arterial Infusion in Breast Cancer Liver Metastases
Combination of CBL0137 HAI with PD-1 blockade improved survival in 4T1 tumors but not in CT26 tumors, and therapeutic efficacy relies on the finding of simultaneous and targeted depletion of myeloid-derived suppressor cells and skewing of T cell populations to produce synergy with PD-1 blockade therapy.
Authors
- Jian‐Min Wang (ORCID: https://orcid.org/0000-0001-9449-9268)
- Sharon S. Evans (ORCID: https://orcid.org/0000-0003-2958-6642)
- Alfiya Safina (ORCID: https://orcid.org/0000-0002-7977-349X)
- Katerina V. Gurova (ORCID: https://orcid.org/0000-0001-9189-0712)
- Joseph J. Skitzki (ORCID: https://orcid.org/0000-0002-3689-2843)
- Siddharth Balachandran (ORCID: https://orcid.org/0000-0003-2084-1803)
- Anuradha Krishnamurthy
- Amy Ku (ORCID: https://orcid.org/0000-0003-3251-5167)
- Andrei V. Gudkov (ORCID: https://orcid.org/0000-0003-2548-0154)
- Minhyung Kim (ORCID: https://orcid.org/0000-0002-5628-1062)
- Colin Powers (ORCID: https://orcid.org/0000-0001-7960-9940)
- Daniel T. Fisher
- Avishekh Gautam (ORCID: https://orcid.org/0000-0002-7849-5360)
- Nickolay Neznanov
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-03
- DOI
- https://doi.org/10.3390/cancers16213711
- Citations
- 4
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.96