Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult
Our approach allowed discerning axonal longitudinal and transverse mechanical insults, which are likely associated with different mechanisms of axonal damage. The technique also enabled quantifying insult along individual axon paths, providing a novel link relating the retinal nerve fiber layer and the optic nerve through the LC via individual axons. This is a promising approach to establish a clearer connection between IOP-induced insult and glaucoma. Further studies should evaluate a larger cohort.
Authors
- Manik Bansal (ORCID: https://orcid.org/0000-0002-2754-2497)
- Yuankai Lu (ORCID: https://orcid.org/0000-0003-3778-4198)
- Brad A. Fortune (ORCID: https://orcid.org/0000-0003-0284-5173)
- Yi Hua (ORCID: https://orcid.org/0000-0003-2399-9884)
- Bingrui Wang (ORCID: https://orcid.org/0000-0002-9260-632X)
- Susannah Waxman (ORCID: https://orcid.org/0000-0001-6708-3187)
- Ian A. Sigal (ORCID: https://orcid.org/0000-0002-0790-7911)
- Juan Reynaud (ORCID: https://orcid.org/0000-0003-2624-9229)
- Fuqiang Zhong
Institutions
- Legacy Health (US)
- University of Pittsburgh (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1167/iovs.65.13.1
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.08
Funders
- Research to Prevent Blindness
- University of Pittsburgh
- Heidelberg Engineering
- National Institutes of Health
- Canadian Institutes of Health Research