Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death
Treatment with a novel VDC (Bel-sar) induced pro-immunogenic cell death in all three CJM cell lines. The in vitro cytotoxicity was accompanied by exposure of DAMPs, suggesting Bel-sar is a potential treatment for CJM by a dual mechanism of action. This dual mechanism may provide a targeted and direct killing of tumor cells and induce an immune response which might decrease local recurrences and metastasis.
Authors
- Martine J. Jager (ORCID: https://orcid.org/0000-0003-2261-3820)
- Sen Ma (ORCID: https://orcid.org/0000-0003-1395-6880)
- Ferry Ossendorp (ORCID: https://orcid.org/0000-0001-9730-7954)
- Elisabet de los Pinos (ORCID: https://orcid.org/0000-0001-7586-002X)
- Ruben V. Huis In't Veld
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1167/iovs.65.13.3
- Citations
- 3
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Leids Universitair Medisch Centrum