Study on the Mechanism of Dictyophora duplicata Polysaccharide in Reducing Depression-like Behavior in Mice
DDP-B1 regulated abnormalities in the glutamatergic system, subsequently activated the BDNF-TrkB-mTOR pathway and mitigated the pathological manifestations of CUMS mice. This study validated the potential of DDP-B1 as an antidepressant medication and established a theoretical foundation for the development of fungi with similar properties.
Authors
- Chenxi Yang (ORCID: https://orcid.org/0000-0003-0180-4126)
- Chunyue Wang (ORCID: https://orcid.org/0000-0002-6161-0879)
- Lanzhou Li
- Yongfeng Zhang (ORCID: https://orcid.org/0000-0002-6949-3064)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0003-1420-2175)
- Yu Li (ORCID: https://orcid.org/0009-0008-7827-5553)
- Jie Tang (ORCID: https://orcid.org/0000-0003-2126-6812)
- Chang‐Chun Ruan
Institutions
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- Jilin Province Science and Technology Department (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- Jilin Agricultural University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3390/nu16213785
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Natural Science Foundation of Jilin Province