PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene
Crotonylation of PTBP1 coordinates tumor cell glycolysis and promotes CRC progression by regulating PKM alternative splicing and increasing PKM2 expression.
Authors
- Lijuan Gao (ORCID: https://orcid.org/0000-0003-3657-3698)
- Fupeng Zhang (ORCID: https://orcid.org/0000-0002-0403-9522)
- Xixing Wang (ORCID: https://orcid.org/0000-0002-9413-0601)
- Shulan Hao
- Ji‐Min Cao (ORCID: https://orcid.org/0000-0002-6546-555X)
- Jianyun Shi
- Xiaoling Wang (ORCID: https://orcid.org/0000-0001-6223-920X)
- Ning Li (ORCID: https://orcid.org/0000-0002-8388-5080)
- Gang Li (ORCID: https://orcid.org/0009-0002-1292-1723)
- Yu Gao (ORCID: https://orcid.org/0009-0009-7655-9015)
- Hong Chang (ORCID: https://orcid.org/0000-0002-6926-8895)
- Jiayi Hou
- Zhijie Wang (ORCID: https://orcid.org/0000-0002-6266-772X)
Institutions
- Shanxi Medical University (CN)
- Shanxi University (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12967-024-05793-5
- Citations
- 15
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- Health Commission of Shanxi Province
- National Natural Science Foundation of China