The role of mitochondrial transfer in the suppression of CD8+ T cell responses by Mesenchymal stem cells
. In this report we showed that MSCs are able to interact with CD8<sup>+</sup> T cells and transfer them their mitochondria. Mitochondrial transfer contributed to the global suppressive effect of MSCs on CD8<sup>+</sup> T cell activation by downregulating T-bet and Eomes expression resulting in impaired IFNγ production of activated CD8<sup>+</sup> T cells.
Authors
- Marie‐Luce Vignais (ORCID: https://orcid.org/0000-0002-0183-5953)
- Jean Nakhle (ORCID: https://orcid.org/0000-0001-9385-6577)
- Matthieu Simon (ORCID: https://orcid.org/0000-0002-9202-1583)
- Christian Jørgensen (ORCID: https://orcid.org/0000-0001-6947-8094)
- Waseem Akhter
- Javier Hernández (ORCID: https://orcid.org/0000-0002-7218-7519)
- Martín Villalba (ORCID: https://orcid.org/0000-0002-4385-4888)
- Loı̈c Vaillant
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Institute for Regenerative Medicine & Biotherapy (FR)
- Institut de Génétique Moléculaire de Montpellier (FR)
- Institut de Génomique Fonctionnelle (FR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s13287-024-03980-1
- Citations
- 13
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 5.69
Funders
- Agence Nationale de la Recherche