High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery
Overall, our study provides insights into the structure-function relationships of ILs, providing a foundation for the rational design of ILs to enhance the efficacy of LNPs in mRNA delivery.
Authors
- Danni Jin
- Haonan Huo
- Jingjiao Li (ORCID: https://orcid.org/0000-0002-7210-2466)
- Xueguang Lu (ORCID: https://orcid.org/0000-0002-1069-7265)
- Ning Chen (ORCID: https://orcid.org/0000-0001-6660-4892)
- Jie Hu (ORCID: https://orcid.org/0000-0002-3368-0183)
- Jiaqi Lin (ORCID: https://orcid.org/0000-0003-3217-864X)
Institutions
- Chinese Academy of Sciences (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12951-024-02919-1
- Citations
- 15
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Institute of Chemistry, Chinese Academy of Sciences