Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole
The genetic basis of variation in sensitivity to acute exposure to 4-methylimidazole in Drosophila is attributable to variation in genes and networks of genes known for their effects on multiple developmental and cellular processes, including possible neurotoxicity. Given evolutionary conservation of the underlying genes and pathways, these insights may be applicable to humans.
Authors
- Rachel A. Lyman (ORCID: https://orcid.org/0000-0001-5203-0744)
- Trudy F. C. Mackay (ORCID: https://orcid.org/0000-0002-2312-7245)
- Nestor O. Nazario-Yepiz (ORCID: https://orcid.org/0000-0002-3511-0109)
- Richard F. Lyman
- Karen Collins (ORCID: https://orcid.org/0000-0002-4317-142X)
- Vijay Shankar (ORCID: https://orcid.org/0000-0002-6446-9030)
- Robert R. H. Anholt (ORCID: https://orcid.org/0000-0001-7196-8324)
- Janet Brooks (ORCID: https://orcid.org/0000-0002-6677-9788)
- Elisabeth Howansky
- Sarah C. Macon-Foley
- Maria E. Adonay
Institutions
- Center for Human Genetics (US)
- Clemson University (US)
Publication Details
- Journal
- Human Genomics
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s40246-024-00689-3
- Citations
- 3
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Institutes of Health