Bone marrow mesenchymal stem cells overexpressing stromal cell- derived factor 1 aid in bone formation in osteoporotic mice
SDF1-BMSCs can further promote bone formation by increasing the number of cells homing to the femur in osteoporotic mice. Our study shows that stem cells can promote their proliferation and home to the femur via the SDF1/CXCR4 axis and further help bone formation via Wnt-1 signaling.
Authors
- Weizhou Wang (ORCID: https://orcid.org/0000-0002-4309-9077)
- Xinyu Yang (ORCID: https://orcid.org/0000-0002-2194-4137)
- Jun Hu (ORCID: https://orcid.org/0000-0002-3038-0206)
- Guang Yang (ORCID: https://orcid.org/0000-0001-5271-7079)
- Fei He (ORCID: https://orcid.org/0000-0002-1681-0265)
- Yanghao Wang (ORCID: https://orcid.org/0000-0001-8325-9867)
- Ya Xiao (ORCID: https://orcid.org/0000-0002-3999-0211)
Institutions
- Kunming Medical University (CN)
- The First Hospital of Kunming (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12891-024-07957-2
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- National Natural Science Foundation of China
- Yunnan Provincial Department of Education Science Research Fund Project