Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?

The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother–child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5·5 years were considered jointly through five allergic and respiratory multimorbidity clusters (‘asymptomatic’ - reference, ‘early wheeze without asthma’, ‘asthma only’, ‘allergies without asthma’ and ‘multi-allergic’). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the ‘early wheeze without asthma’ cluster (aOR (95 % CI) = 0·95 (0·90, 0·99) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the ‘asthma only’ cluster (aOR (95 % CI) = 1·09 (1·00, 1·19) per sd). No association was found with the ‘allergies without asthma’ or ‘multi-allergic’ clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5·5 years, though the associations were weak.

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Publication Details

Journal
British Journal Of Nutrition
Published
2024-11-04
DOI
https://doi.org/10.1017/s0007114524002642
Citations
3
Primary Topic
Neonatal Respiratory Health Research
Type
article
Field-Weighted Citation Impact
1.26

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article

Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?

Annabelle Bédard, Marie‐Noëlle Dufourg, Courtney Dow, Chantal Rahérison et al.
3 citations
British Journal Of Nutrition
Neonatal Respiratory Health Research
1.26
article

Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?

Annabelle Bédard, Marie‐Noëlle Dufourg, Courtney Dow, Chantal Rahérison, Marie-Aline A Charles, Raphaëlle Varraso, Rosalie Delvert, Bénédicte Leynaert, Blandine de Lauzon‐Guillain, Amandine Divaret‐Chauveau, Karine Adel‐Patient
article en
3 citations

Abstract

The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother–child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5·5 years were considered jointly through five allergic and respiratory multimorbidity clusters (‘asymptomatic’ - reference, ‘early wheeze without asthma’, ‘asthma only’, ‘allergies without asthma’ and ‘multi-allergic’). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the ‘early wheeze without asthma’ cluster (aOR (95 % CI) = 0·95 (0·90, 0·99) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the ‘asthma only’ cluster (aOR (95 % CI) = 1·09 (1·00, 1·19) per sd). No association was found with the ‘allergies without asthma’ or ‘multi-allergic’ clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5·5 years, though the associations were weak.

British Journal Of NutritionVol. 132(10)
Université Paris-Sud (FR), Institut national d'études démographiques (FR), Université de Bordeaux (FR), Inserm (FR), Université de Versailles Saint-Quentin-en-Yvelines (FR), Université Paris Cité (FR), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR), Université Paris-Saclay (FR), Sorbonne Université (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Université Sorbonne Paris Nord (FR), Centre Hospitalier Régional et Universitaire de Nancy (FR), Centre de recherche en Epidémiologie et Santé des Populations (FR), Hôpital d'Enfants (FR), Bordeaux Population Health (FR), Direction des Energies (FR), CEA Paris-Saclay (FR), Établissement Français du Sang (FR), Centre Hospitalier Universitaire Pointe-à-Pitre (GP), Développement, Adaptation et Handicap, Établissement public Campus Condorcet (FR), Centre de Recherche Épidémiologie et Statistique (FR), Etude longitudinale française depuis l'enfance, Université de Lorraine (FR)
AstraZeneca, Sanofi, Mead Johnson Nutrition, Aimmune Therapeutics, University of Cambridge, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Socialdepartementet, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Etablissement Français du Sang
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Openalex Percentile: Top 18%
Neonatal Respiratory Health Research
1.26
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