Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study

Study DesignRetrospective study.ObjectivesTo investigate the impact of diabetes mellitus on neurological recovery and determine the relationship between moderate-severe diabetes and neurological recovery in patients with cervical spinal cord injury (CSCI) without bone injury.MethodsA retrospective study was conducted on 389 consecutive patients aged ≥65 years with CSCI without bone injury across 33 medical institutes. The patients were divided into a nondiabetic group (n = 270) and a diabetic group (n = 119). Neurological outcomes were compared between the two groups through propensity score matching. The impact of moderate-severe diabetes (defined as hemoglobin A1c ≥ 7.0% or requiring insulin treatment) on neurological recovery was evaluated through multiple linear regression analysis.ResultsPropensity score matching revealed no significant differences between the diabetic and nondiabetic groups in terms of American Spinal Injury Association (ASIA) impairment scale grade and mean total ASIA motor scores (AMS) at 6 months post-injury. Multiple linear regression analysis indicated that age on admission (B = -0.34; 95% confidence interval [CI], -0.59 to -0.08; <i>P</i> = 0.01), dementia (B = -16.50; 95% CI, -24.99 to -8.01; <i>P</i> < 0.01), and baseline total AMS (B = -0.62; 95% CI, -0.72 to -0.51; <i>P</i> < 0.01) were negative predictors of neurological recovery at 6 months post-injury. The presence of moderate-severe diabetes did not influence neurological recovery at 6 months post-injury.ConclusionsDiabetic patients with CSCI without bone injury achieved improvements in neurological function comparable to those of nondiabetic patients. Moderate-severe diabetes did not affect neurological recovery in patients with CSCI without bone injury.

Authors

Institutions

Publication Details

Journal
Global Spine Journal
Published
2024-11-04
DOI
https://doi.org/10.1177/21925682241297587
Primary Topic
Spinal Cord Injury Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study

Takashi Kaito, Shiro Imagama, Yasuaki Imajo, Hideaki Nakajima et al.
Global Spine Journal
Spinal Cord Injury Research
article

Influence of Diabetes Mellitus on Neurological Recovery in Older Patients With Cervical Spinal Cord Injury Without Bone Injury: A Retrospective Multicenter Study

Takashi Kaito, Shiro Imagama, Yasuaki Imajo, Hideaki Nakajima, Fumihiko Eto, Hiroshi Uei, Katsuhito Kiyasu, Takeo Furuya, Haruki Funao, Hidetomi Terai, Ko Hashimoto, Noriaki Yokogawa, Shota Ikegami, Tomohiro Yamada, Seiji Okada, Ryosuke Hirota, Hitoshi Kono, Toshitaka Yoshii, Satoshi Kato, Tomohiko Hasegawa, Hiroaki Nakashima, Satoshi Nori, Masayuki Ishihara, Hitoshi Tonomura, Koji Akeda, Munehiro Sakata, Yoichi Iizuka, Hidenori Suzuki, Kazuo Nakanishi, Gen Inoue, Yasushi Oshima, Yoshinori Terashima, Junichi Yamane, Toru Funayama, Kota Watanabe, Naoki Segi, Kazuki Takeda, Takeshi Sasagawa, Atsushi Yunde, Norihiro Suzuki, Kenichi Kawaguchi
article en

Abstract

Study DesignRetrospective study.ObjectivesTo investigate the impact of diabetes mellitus on neurological recovery and determine the relationship between moderate-severe diabetes and neurological recovery in patients with cervical spinal cord injury (CSCI) without bone injury.MethodsA retrospective study was conducted on 389 consecutive patients aged ≥65 years with CSCI without bone injury across 33 medical institutes. The patients were divided into a nondiabetic group (n = 270) and a diabetic group (n = 119). Neurological outcomes were compared between the two groups through propensity score matching. The impact of moderate-severe diabetes (defined as hemoglobin A1c ≥ 7.0% or requiring insulin treatment) on neurological recovery was evaluated through multiple linear regression analysis.ResultsPropensity score matching revealed no significant differences between the diabetic and nondiabetic groups in terms of American Spinal Injury Association (ASIA) impairment scale grade and mean total ASIA motor scores (AMS) at 6 months post-injury. Multiple linear regression analysis indicated that age on admission (B = -0.34; 95% confidence interval [CI], -0.59 to -0.08; <i>P</i> = 0.01), dementia (B = -16.50; 95% CI, -24.99 to -8.01; <i>P</i> < 0.01), and baseline total AMS (B = -0.62; 95% CI, -0.72 to -0.51; <i>P</i> < 0.01) were negative predictors of neurological recovery at 6 months post-injury. The presence of moderate-severe diabetes did not influence neurological recovery at 6 months post-injury.ConclusionsDiabetic patients with CSCI without bone injury achieved improvements in neurological function comparable to those of nondiabetic patients. Moderate-severe diabetes did not affect neurological recovery in patients with CSCI without bone injury.

Global Spine JournalVol. 15(4)
Kanazawa University (JP), Nihon University (JP), University of Fukui (JP), Tokyo Medical and Dental University (JP), Kansai Medical University (JP), Tokuyama (Japan) (JP), Kyushu University (JP), Shinshu University (JP), Sapporo Medical University (JP), University of Tsukuba (JP), Chiba University (JP), Gunma University (JP), Yamaguchi University (JP), Mie University (JP), Kawasaki Medical School (JP), Tohoku University (JP), University of Kochi (JP), Keio University (JP), Hamamatsu University School of Medicine (JP), Nagoya City University (JP), Kyoto Prefectural University of Medicine (JP), Toyama Prefectural Central Hospital (JP), Kochi Medical School Hospital (JP), National Hospital Organization Mito Medical Center (JP), University of Tokyo Hospital (JP), Hiroshima Kyoritsu Hospital (JP), Hokkaido Orthopedic Surgery Memorial Hospital (JP), Murayama Medical Center (JP), Shizuoka Red Cross Hospital (JP), Keiyu Orthopedic Hospital (JP), National Hospital Organization (JP), keiyu Hospital (JP), Saiseikai Shigaken Hospital (JP), Mita Hospital (JP), Ōtani University (JP), Osaka Metropolitan University (JP), Nagoya University (JP), Kitasato University (JP), The University of Tokyo (JP), Kōchi University (JP), International University of Health and Welfare (JP), Graduate School USA (US), The University of Osaka (JP)
Good health and well-being
Openalex Percentile: Top 68%
Spinal Cord Injury Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.