Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder
S1PR1 may contribute to PAI in the PNS in ASD. The mechanism involves KCNQ/M channels and the MAPK and cAMP/PKA signaling pathways. Targeting S1PR1 in the PNS could offer novel therapeutic strategies for the intervention of pain dysesthesias in individuals with ASD.
Authors
- Yaqi Sun (ORCID: https://orcid.org/0000-0002-2175-7905)
- Yaxin Shi
- Xirui Zhang (ORCID: https://orcid.org/0009-0000-0344-4502)
- Anjie Chen
- Yutong Liu (ORCID: https://orcid.org/0000-0001-5498-1324)
- Lili Fan (ORCID: https://orcid.org/0000-0002-2114-4463)
- Xiang Li (ORCID: https://orcid.org/0000-0002-9168-1598)
- Yuan Yang (ORCID: https://orcid.org/0000-0002-9206-0312)
- Qi Li (ORCID: https://orcid.org/0000-0002-0163-9987)
- Jia Wang (ORCID: https://orcid.org/0000-0002-5978-4191)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0003-3091-4471)
- Lijie Wu (ORCID: https://orcid.org/0000-0002-0631-5076)
Institutions
- Harbin Medical University (CN)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12916-024-03722-3
- Citations
- 2
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Harbin Medical University
- National Natural Science Foundation of China