The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse
PX-478 demonstrates a therapeutic potential in the mice POP model. It reduces vaginal length, attenuates fibrosis, and modulates collagen synthesis. Its immunomodulation is evident through reduced M1 and M2 macrophages and suppressed IL-18 secretion.
Authors
- Chunfang Duan
- Duanqing Wu
- Xiao-Hui Mei
- Ying Yang (ORCID: https://orcid.org/0000-0002-2032-9183)
- Yuqi Yang (ORCID: https://orcid.org/0000-0003-2255-850X)
- Jun Ye (ORCID: https://orcid.org/0000-0003-3382-4412)
- Rujun Chen (ORCID: https://orcid.org/0000-0002-9451-6280)
- Weimin Fan (ORCID: https://orcid.org/0000-0002-2149-3014)
- Liwen Zhang (ORCID: https://orcid.org/0000-0002-3518-2815)
- Ke Sun (ORCID: https://orcid.org/0000-0002-3789-3143)
Institutions
- Fudan University (CN)
- The People's Hospital Tongling (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Obstetrics and Gynaecology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1080/01443615.2024.2415669
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00