Outcomes After Stereotactic Body Radiation for Hepatocellular Carcinoma in Patients With Child-Pugh A Versus Child-Pugh B/C Cirrhosis
Our findings suggest that SBRT is feasible and effective in patients with both CP A and CP B/C liver dysfunction with similar rates of local control and pathologic complete response despite lower radiation doses in the CP B/C cohort. In patients with more advanced CP B/C cirrhosis, toxicities were higher and must be weighed against possible treatment benefits. Further studies characterizing the optimal role of SBRT in patients with advanced cirrhosis are warranted.
Authors
- Thomas J. FitzGerald (ORCID: https://orcid.org/0000-0002-6256-0615)
- Kara Banson (ORCID: https://orcid.org/0000-0002-2689-0529)
- Utkarsh Shukla
- Brett Diamond (ORCID: https://orcid.org/0000-0002-4663-0054)
- Paul Rava (ORCID: https://orcid.org/0000-0001-7291-8863)
- Jonathan Ayash
- Shirin Sioshansi
- Gavin W. Jones (ORCID: https://orcid.org/0000-0001-7114-5053)
- Peter Lee (ORCID: https://orcid.org/0000-0002-7897-3721)
Institutions
- Fox Chase Cancer Center (US)
- Tufts Medical Center (US)
- Memorial Medical Center (US)
- New Mexico Cancer Center (US)
- UMass Memorial Medical Center (US)
- New York University (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1016/j.adro.2024.101631
- Citations
- 5
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.85