Long-Lasting Exendin-4-Coated Gold Nanoparticles: Synthesis and In Vivo Evaluation of Hypoglycemic Activity
Overall, this study demonstrated that the preparation of therapeutic protein-loaded gold NPs is feasible and, despite their much larger size compared with the protein, EX-ABD-AFF-GoldNPs can be successfully absorbed through the subcutaneous route and show nearly equivalent hypoglycemic activity to the EX-ABD-AFF protein. Finally, this study showed that long-lasting properties could be acquired by only coating EX-ABD-AFF onto gold NPs.
Authors
- Reeju Amatya (ORCID: https://orcid.org/0000-0002-1724-6619)
- Amala Joseph
- Kyoung Ah Min (ORCID: https://orcid.org/0000-0002-0767-4927)
- Yassmine Benmokadem
- Gu Seob Roh (ORCID: https://orcid.org/0000-0003-4010-9628)
- Meong Cheol Shin (ORCID: https://orcid.org/0000-0001-8035-923X)
Institutions
- Inje University (KR)
- Gyeongsang National University (KR)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-11-02
- DOI
- https://doi.org/10.3390/ph17111475
- Citations
- 4
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Research Foundation of Korea