The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells
Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell's elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.
Authors
- Ekaterina Sherstyukova (ORCID: https://orcid.org/0000-0002-9962-6315)
- Snezhanna Kandrashina (ORCID: https://orcid.org/0000-0002-2185-3817)
- В. А. Сергунова (ORCID: https://orcid.org/0000-0002-8425-0845)
- Maxim Dokukin (ORCID: https://orcid.org/0000-0001-6856-1953)
- Vladimir Inozemtsev (ORCID: https://orcid.org/0000-0002-4693-5624)
- Roman V. Timoshenko (ORCID: https://orcid.org/0009-0007-6459-6455)
- Alexander Erofeev
- Mikhail Shvedov
Institutions
- National University of Science and Technology (RU)
- V.A. Negovsky Scientific Research Institute of General Reanimatology (RU)
- Sarov Institute of Physics and Technology (RU)
- National Research Nuclear University MEPhI (RU)
Publication Details
- Journal
- Cells
- Published
- 2024-11-03
- DOI
- https://doi.org/10.3390/cells13211813
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.63