Application of Integrated Optical Density in Evaluating Insulin Expression in the Endocrine Pancreas During Chronic Ethanol Exposure and β-Carotene Supplementation: A Novel Approach Utilizing Artificial Intelligence
In mice, β-cell loss led to increased glucose release due to decreased insulin levels. β-carotene appeared to mitigate ethanol's impact on these cells, resulting in reduced insulin degradation when integrated optical density was used. These findings suggest that antioxidant supplementation may be beneficial in treating ethanol-induced type 2 diabetes in animal models.
Authors
- Karina Godoy (ORCID: https://orcid.org/0000-0003-4208-4540)
- Cristian Sandoval (ORCID: https://orcid.org/0000-0003-3184-6482)
- Francisco Torrens (ORCID: https://orcid.org/0000-0002-8534-208X)
- Jorge G. Farías (ORCID: https://orcid.org/0000-0001-7660-9603)
- F Montero Venegas
- José Carlos Caamaño (ORCID: https://orcid.org/0000-0002-9572-9982)
- Álvaro Hoyos Orrego
- Bélgica Vásquez (ORCID: https://orcid.org/0000-0002-4106-3548)
- Ángeles Vera
- Camila Reyes
- Mauricio Zamorano (ORCID: https://orcid.org/0000-0002-4559-4653)
- Luciano Canobbi
Institutions
- Universidad de La Frontera (CL)
- Universitat de València (ES)
- Universidad Santo Tomás (CL)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-11-03
- DOI
- https://doi.org/10.3390/ph17111478
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de La Frontera
- Agencia Nacional de Investigación y Desarrollo