Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability
Collectively, our study elucidates that mechanical force induces arginine methylation of Kindlin-2, thereby regulating vascular stability through its impact on Kindlin-2 LLPS. Targeting Kindlin-2 arginine methylation emerges as a promising hemodynamic-based strategy for treating vascular disorders and atherosclerosis.
Authors
- Junhao Hu (ORCID: https://orcid.org/0000-0003-0699-1119)
- Bochuan Li (ORCID: https://orcid.org/0000-0003-1670-2077)
- Fangfang Wu (ORCID: https://orcid.org/0000-0003-4193-4187)
- Xi Fang (ORCID: https://orcid.org/0000-0001-7816-8821)
- Xue Dong (ORCID: https://orcid.org/0009-0003-1233-8674)
- Ziru Wu (ORCID: https://orcid.org/0009-0005-5091-6089)
- Nina Ma
- Heng Zhang (ORCID: https://orcid.org/0000-0003-1112-7149)
- Ding Ai (ORCID: https://orcid.org/0000-0001-5992-9904)
- Lu Wang (ORCID: https://orcid.org/0009-0002-7375-5220)
- Xiaohong Wang (ORCID: https://orcid.org/0000-0001-8628-243X)
- Jiayu Liu (ORCID: https://orcid.org/0000-0001-5086-5502)
- Jing Zhou (ORCID: https://orcid.org/0000-0002-2211-4901)
- Yuming Liu
Institutions
- Peking University (CN)
- Tianjin Medical University General Hospital (CN)
- University of California San Diego (US)
- Shanghai Institute of Organic Chemistry (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1161/circresaha.124.324773
- Citations
- 8
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87