Formulation and Evaluation of Mucoadhesive Microsphere of Esomeprazole and Domperidone

Purpose: To prepare and evaluate mucoadhesive microsphere of esomeprazole and domperidone for the treatment of gastroesophageal reflux disease Methods: The microspherewere prepared by solvent evaporation technique by using sodium carboxy methyl cellulose and sodium alginate as polymer. Esomeprazole and Domperidone was entrapped in the microsphere at various polymer. The microsphere were evaluated for their micromeretic properties and in- vitro release. Results: The microspheres were discrete, spherical and showed good drug entrapment efficiency. Results indicate that the drug was compatible with the polymer used. Amongst all the formulations, F6 showed the most suitable sustain release properties with 97.75 % of drug released at the end of 24 hrs. Conclusion: Microsphere prepared using sodium carboxy methyl cellulose and sodium alginate can be used as a sustained release delivery system for esomeprazole and domperidone.