Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification
In summary, our results provide a mechanistic insight into the critical role of ROCK1 in lysosomal regulation and Aβ clearance in AD by acting as a novel upstream serine kinase of TFEB.
Authors
- Hongzhuan Chen (ORCID: https://orcid.org/0000-0002-5367-2949)
- Pingao Zhang
- Jiyun Shi
- Ting Yu (ORCID: https://orcid.org/0000-0001-5858-5177)
- Chenghuan Song
- Gang Wang (ORCID: https://orcid.org/0000-0001-6500-5863)
- Jing Wang (ORCID: https://orcid.org/0000-0002-8117-8657)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-0699-3077)
- Wan‐Ying Huang (ORCID: https://orcid.org/0000-0003-0461-7182)
- Lan‐Xue Zhao
- Hao Wang (ORCID: https://orcid.org/0000-0002-2010-9906)
- Yongfang Zhang
- Yongbo Hu
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s40035-024-00442-9
- Citations
- 11
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation