Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Our results provide evidence that DPSCs-CM, produced under hypoxic conditions, can be proposed as a tool able to support angiogenesis via macrophage polarization, suggesting its use to overcome the issues and restrictions associated with the use of staminal cells.
Authors
- Matteo Gallazzi (ORCID: https://orcid.org/0000-0001-6662-9352)
- Antonino Bruno (ORCID: https://orcid.org/0000-0002-4790-0861)
- Federica Rossi (ORCID: https://orcid.org/0000-0001-5983-3646)
- Ludovica Barone (ORCID: https://orcid.org/0000-0002-8553-222X)
- G. Antoni
- Giovanni Bernardini (ORCID: https://orcid.org/0000-0002-3545-0103)
- Piero Antonio Zecca (ORCID: https://orcid.org/0000-0001-9646-4958)
- Rosalba Gornati (ORCID: https://orcid.org/0000-0002-1544-2122)
- Mario Raspanti (ORCID: https://orcid.org/0000-0001-6322-1845)
- Roberto Papait (ORCID: https://orcid.org/0000-0002-9552-8259)
- Maria Teresa Palano
- Martina Cucchiara (ORCID: https://orcid.org/0000-0003-0030-5149)
- Christina Pagiatakis (ORCID: https://orcid.org/0000-0002-9315-9648)
- Barbara Bassani (ORCID: https://orcid.org/0000-0002-8002-1607)
Institutions
- University of Insubria (IT)
- MultiMedica (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-11-04
- DOI
- https://doi.org/10.1186/s12929-024-01087-6
- Citations
- 16
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 7.01