Immortalization of patient-derived lip cells for establishing 3D lip models
The establishment of immortalized keratinocytes derived from healthy and cleft lips represents a significant achievement in lip research. These cell lines and the associated three-dimensional lip models are valuable tools that can be used as convenient screening platforms for various assays in a multitude of lip-related research areas, including dermatology, skin care, wound healing, tissue engineering, and craniofacial anomalies. This work opens new avenues in studying lip abnormalities and provides unique tools for personalized medicine approaches beneficial to patients.
Authors
- Martin Degen (ORCID: https://orcid.org/0000-0002-4356-3714)
- Farah Mansour
- Giorgio C. La Scala (ORCID: https://orcid.org/0000-0003-1572-598X)
- Ludovica Parisi (ORCID: https://orcid.org/0000-0002-4673-3176)
- Christos Katsaros (ORCID: https://orcid.org/0000-0001-5545-6740)
- Isabelle Schnyder
- Nijas Aliu
- Silvia Rihs
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- University Hospital of Geneva (CH)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3389/fcell.2024.1449224
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bern