Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model
This single-cell analysis builds upon our understanding of the impact of Ad-IFNα on tumor cells and other compartments of the microenvironment. These data will help identify mechanisms to improve patient selection and therapeutic efficacy of Nadofaragene firadenovec.
Authors
- Colin P. Dinney (ORCID: https://orcid.org/0000-0002-8969-711X)
- Chinnaswamy Jagannath
- Seppo Ylä‐Herttuala (ORCID: https://orcid.org/0000-0001-7593-2708)
- Sharada Mokkapati
- Alberto Martini (ORCID: https://orcid.org/0000-0003-1272-7154)
- Nigel Parker
- Burles A. Johnson (ORCID: https://orcid.org/0000-0002-7180-8790)
- Côme Tholomier
- Alexis Steinmetz (ORCID: https://orcid.org/0000-0002-5833-851X)
- David J. McConkey (ORCID: https://orcid.org/0000-0003-1971-0638)
- Bogdan Czerniak (ORCID: https://orcid.org/0000-0002-8289-9173)
- Byron Lee (ORCID: https://orcid.org/0000-0002-8755-9688)
- Ganiraju C. Manyam
- Jonathan J. Duplisea
- Yan Chen (ORCID: https://orcid.org/0000-0003-3516-9546)
- Anil K. Sood (ORCID: https://orcid.org/0000-0002-5415-9901)
- M Pierce
Institutions
- Houston Methodist (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Institute for Molecular Medicine Finland (FI)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3389/fimmu.2024.1387229
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- University of Texas MD Anderson Cancer Center