Experience of rescue therapy with [177Lu]Lu-rhPSMA-10.1 in patients with primary or acquired resistance to [177Lu]Lu-PSMA-I&T

Patients showing tumour progression while receiving [<sup>177</sup>Lu]Lu-PSMA-I&T radioligand therapy may benefit from rescue therapy with the novel radiohybrid PSMA ligand, [<sup>177</sup>Lu]Lu-rhPSMA-10.1. Higher tumour absorbed radiation doses with [<sup>177</sup>Lu]Lu-rhPSMA-10.1 may overcome primary and acquired radiation resistance.

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Publication Details

Journal
European Journal of Nuclear Medicine and Molecular Imaging
Published
2024-11-04
DOI
https://doi.org/10.1007/s00259-024-06959-5
Citations
8
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
3.35
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article

Experience of rescue therapy with [177Lu]Lu-rhPSMA-10.1 in patients with primary or acquired resistance to [177Lu]Lu-PSMA-I&T

Ralph A. Bundschuh, H. Kempter, Alexander Gäble, Kazuhito Fukushima et al.
8 citations
European Journal of Nuclear Medicine and Molecular Imaging
Prostate Cancer Treatment and Research
3.35
article

Experience of rescue therapy with [177Lu]Lu-rhPSMA-10.1 in patients with primary or acquired resistance to [177Lu]Lu-PSMA-I&T

Ralph A. Bundschuh, H. Kempter, Alexander Gäble, Kazuhito Fukushima, Martin Trepel, Andreas Rinscheid, Tilman Janzen, Dorothea Weckermann, Georgine Wienand, Marianne Patt, Malte Kircher, Johanna S. Enke, Ana Nikolić, Julie Steinestel, Constantin Lapa, Christian H. Pfob, Alexander Dierks
article en
8 citations

Abstract

Patients showing tumour progression while receiving [<sup>177</sup>Lu]Lu-PSMA-I&T radioligand therapy may benefit from rescue therapy with the novel radiohybrid PSMA ligand, [<sup>177</sup>Lu]Lu-rhPSMA-10.1. Higher tumour absorbed radiation doses with [<sup>177</sup>Lu]Lu-rhPSMA-10.1 may overcome primary and acquired radiation resistance.

European Journal of Nuclear Medicine and Molecular ImagingVol. 52(3)
Kobe International University (JP), Technische Hochschule Augsburg (DE), University of Augsburg (DE), University Hospital Augsburg (DE), BUND Naturschutz (DE)
Good health and well-being
Openalex Percentile: Top 7%
Prostate Cancer Treatment and Research
3.35
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