Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction
Tofacitinib treatment in JIA down-regulated genes in interferon and IL-7 signaling pathways regardless of effectiveness. Furthermore, baseline up-regulation of MAPK signaling may predict poor response to tofacitinib treatment in JIA.
Authors
- Esraa M. Eloseily (ORCID: https://orcid.org/0000-0002-4770-7383)
- Hermine I. Brunner (ORCID: https://orcid.org/0000-0001-9478-2987)
- Sherry Thornton (ORCID: https://orcid.org/0000-0002-4271-236X)
- Sanjeev Dhakal
- Alex Pickering
- Nicolino Ruperto (ORCID: https://orcid.org/0000-0001-8407-7782)
- Alexei A. Grom
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Harvard University (US)
- Azienda Ospedaliera San Gerardo (IT)
- University of Cincinnati (US)
- The University of Texas Southwestern Medical Center (US)
- Assiut University (EG)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1002/acr.25459
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Pfizer
- Cincinnati Children's Hospital Medical Center
- University of Cincinnati
- Dr. Ralph and Marian Falk Medical Research Trust
- National Institutes of Health