Sex influence on serotonergic modulation of the vascular noradrenergic drive in rats
In female rats, vascular serotonergic sympatholytic effects are due to prejunctional 5-HT<sub>1D</sub> receptor activation, whereas pre and/or postjunctional 5-HT<sub>3</sub> and prejunctional 5-HT<sub>2A</sub> receptor activation is involved in the potentiating effect of vascular sympathetic neurotransmission. These findings may open novel sex-differential therapeutic strategies for treating cardiovascular conditions.
Authors
- María Luisa Martín (ORCID: https://orcid.org/0000-0003-4810-9673)
- Anaïs Clara Terol‐Úbeda (ORCID: https://orcid.org/0000-0001-6712-804X)
- Juan Francisco Fernández‐González (ORCID: https://orcid.org/0000-0002-2344-4523)
- José Ángel García‐Pedraza (ORCID: https://orcid.org/0000-0002-5252-9470)
- Asunción Morán (ORCID: https://orcid.org/0000-0001-7509-1232)
- Mónica García (ORCID: https://orcid.org/0000-0001-6140-4322)
- Carlos Andrés Roldán‐Hernández
Institutions
- Universidad de Salamanca (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1111/bph.17380
- Citations
- 1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.40