Cognitive improvement via cortical cannabinoid receptors and choline‐containing lipids
We hypothesise that WIN55,212-2 facilitates an alternative choline source by breaking down sphingomyelins, leading to elevated cortical acetylcholine levels and LPCs. These results imply that altering choline-containing lipids via activation of cannabinoid receptors presents a promising therapeutic approach for dementia linked to cholinergic dysfunction.
Authors
- Iker Bengoetxea de Tena (ORCID: https://orcid.org/0000-0003-0586-1857)
- Jonatan Martínez‐Gardeazabal (ORCID: https://orcid.org/0000-0002-0701-9076)
- Alberto Llorente‐Ovejero (ORCID: https://orcid.org/0000-0001-8536-197X)
- Estíbaliz González de San Román (ORCID: https://orcid.org/0000-0001-5440-2695)
- Marta Moreno‐Rodríguez (ORCID: https://orcid.org/0000-0002-9980-9365)
- Laura Lombardero (ORCID: https://orcid.org/0000-0002-3193-8347)
- Rafael Rodríguez‐Puertas (ORCID: https://orcid.org/0000-0003-4517-5114)
- Lydia Giménez‐Llort (ORCID: https://orcid.org/0000-0002-4091-489X)
- Iván Manuel (ORCID: https://orcid.org/0000-0003-0958-4738)
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of the Basque Country (ES)
- BioCruces Health research Institute (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1111/bph.17381
- Citations
- 7
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 3.13