Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis
Our findings suggest that MSCs and MSC-EVs are an effective approach to mitigate DILI. Targeting the miR-186-5p/CXCL1 axis is a promising approach to improve the efficacy of MSCs and MSC-EVs in the treatment of DILI.
Authors
- Panlong Li
- Erming Zhao
- Shuhan Chen (ORCID: https://orcid.org/0000-0002-0324-9026)
- Yana Zhang (ORCID: https://orcid.org/0000-0003-0405-2943)
- Yingcai Zhang (ORCID: https://orcid.org/0000-0002-3086-2440)
- Qiuli Liu (ORCID: https://orcid.org/0000-0002-8090-8718)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-2485-441X)
- Di Lu (ORCID: https://orcid.org/0000-0002-2315-8412)
- Rukang Liang
- Yunfei Qin (ORCID: https://orcid.org/0009-0001-7099-9708)
- Weikeng Tan
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1186/s13287-024-03995-8
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China