Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway
LDHA in kidney tubular cells significantly was increased in HUA models. LDHA mediates kidney inflammation response induced by uric acid through the ROS/NLRP3 pathway. This study may provide a new intervention target for preventing kidney tubular inflammation caused by uric acid.
Authors
- Jiangnan Huang (ORCID: https://orcid.org/0000-0001-8678-6371)
- Jun Ouyang (ORCID: https://orcid.org/0000-0003-4071-7906)
- Yehua Gan (ORCID: https://orcid.org/0000-0002-7806-8174)
- Hui Wang (ORCID: https://orcid.org/0000-0002-3558-0055)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Clinical and Experimental Hypertension
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1080/10641963.2024.2424834
- Citations
- 4
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China